The endocannabinoid system (ECS) is a complex network of receptors, ligands, and enzymes that modulates various physiological processes in the human body. However, despite its critical role in human health and disease, the ECS and its components have not been adequately included in many popular medical textbooks, such as the ‘Guyton and Hall Textbook of Medical Physiology’. This article highlights the importance of incorporating the ECS and its therapeutic potential into medical education, as most doctors are not trained in the ECS and consequently have inadequate knowledge about the potential therapeutic uses of medical cannabis.
Explore the complex dynamics of CB1 receptor downregulation in patients on long-term medical cannabis treatment. We unravel both potential benefits and risks of this phenomenon, impacting therapeutic efficacy and side effects. Essential reading for healthcare professionals prescribing medical cannabis.