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Discover how an evidence-based educational intervention dramatically shifted public attitudes towards cannabis in Sinaloa, Mexico—a region historically entangled with repressive drug policies. This study highlights the transformative power of factual information and offers insights for policymakers and public health experts alike.
Discover groundbreaking research on the analgesic effects of endocannabinoids 2-AG, 2-PG, and 2-LG on TRPV1 receptors in cultured DRG neurons. This study provides invaluable insights into pain management and suggests novel avenues for drug development.
Explore the first-of-its-kind umbrella review, published in the prestigious BMJ, that synthesizes evidence on cannabis use through the lens of the GRADE framework. Understand the potential medical benefits, risks, and the societal implications of cannabis as compared to alcohol. This analysis serves as a cornerstone for clinicians, policymakers, and stakeholders.
Investigating the synergistic effects of cannabinoids 331-18A, CBDV, and CBD, this groundbreaking study targets NOTCH1-Mutated T-Cell Lymphoblastic Acute Leukemia (T-ALL) through the Integrated Stress Response Pathway. By exploring the ‘entourage effect’ with a combination of specific phytocannabinoids, the research opens up new therapeutic horizons, shedding light on the intricate molecular interactions and their potential in cancer treatment.
This groundbreaking study explores the acute neurological effects of THC, focusing on functional connectivity, genetic modulation, physiological implications, and more. Uncover how THC impacts the brain’s communication patterns, how specific genotypes react differently, and the broader context of these findings within the endocannabinoid system or Master Homeostatic Regulatory System (MHRS).
In a revealing international survey, Syed et al. delve into the knowledge, attitudes, and practices of physicians regarding medical cannabis. With responses from 17 countries, the study uncovers significant gaps in understanding and highlights the urgent need for enhanced medical education on this topic.
Explore the nuanced understanding of the ‘high’ associated with medical cannabis use. This article, based on a recent study, challenges traditional perceptions and invites readers to consider the ‘high’ as a separate phenomenon that may not interfere with the therapeutic benefits of cannabis.
In this blog post, we provide a summary of a recent review article published in the Journal of Cannabis Research by O’Sullivan et al. on June 13th. The review focuses on the use of purified CBD products in clinical studies to determine potential indications for which purified CBD could be beneficial. While the findings suggest that purified CBD can be effective in various conditions beyond epilepsy, the evidence base is limited due to trials primarily investigating acute effects, trials conducted on healthy volunteers, and trials with small patient populations. To establish the efficacy of purified CBD across different indications, large confirmatory phase 3 trials are necessary. Join us as we delve into the therapeutic benefits of purified CBD for various conditions based on randomized controlled trials and explore the strengths and weaknesses of the review.
In the groundbreaking study “Postsynaptic Synucleins Mediate Endocannabinoid Signaling,” Eddy Albarran and colleagues delve into the intricate dance between synucleins and endocannabinoids within postsynaptic neurons. Their findings shed light on the potential role of phytocannabinoids in alleviating symptoms of Parkinson’s disease, offering a fresh perspective on therapeutic strategies
Unravel the science behind the influence of tobacco, alcohol, and cannabis on our DNA. Dive into the impact of these substances on DNA methylation and learn how these lifestyle choices can modify gene activity, potentially affecting health outcomes.